Leflunomide: What It Is, How It Works, and What to Watch For

If you’ve been prescribed leflunomide, you probably wonder why your doctor chose it and what to expect. Leflunomide is an oral disease‑modifying drug most often used for rheumatoid arthritis. It slows down the immune system’s attack on joints, which helps reduce pain, swelling, and long‑term damage.

Unlike painkillers that just mask symptoms, leflunomide targets the underlying inflammation. It does this by blocking an enzyme that cancer‑like cells need to multiply. The result is fewer immune cells causing joint destruction. Most people start seeing improvement within a few weeks, but the full effect can take up to three months.

How to Take Leflunomide Safely

Take leflunomide exactly as your doctor orders. The usual starting dose is 100 mg once daily for the first three days, then you drop to 20 mg daily for maintenance. Swallow the tablet with a full glass of water; you don’t need to take it with food.

Because the drug stays in your body for a long time, your doctor will likely order blood tests before you begin and periodically afterward. Those tests check liver function and blood cell counts. If any values look off, your dose might be lowered or you could be asked to stop temporarily.

Never stop leflunomide abruptly without talking to your doctor. If you need to quit, a special “wash‑out” procedure using cholestyramine may be required to clear the drug faster and avoid flare‑ups.

Common Interactions and Precautions

Leflunomide can interact with several other meds. Blood thinners like warfarin may become more potent, so your clotting numbers need close monitoring. Combining leflunomide with other immunosuppressants (for example, methotrexate) can increase infection risk. If you’re on a live vaccine, delay it until you’ve been off leflunomide for a while.

Alcohol, over‑the‑counter pain relievers, and herbal supplements that affect the liver should be used cautiously. Always tell your pharmacist about every product you’re taking.

Women who are pregnant, planning to get pregnant, or could become pregnant should avoid leflunomide. It can cause birth defects. If pregnancy occurs, a rapid‑clearance protocol must be started immediately.

Common side effects include mild nausea, diarrhea, and headache. More serious issues—like liver inflammation or low blood counts—are rarer but need prompt medical attention. If you feel unusually tired, see bruises appearing, or notice yellowing of the skin or eyes, call your doctor right away.

When it comes to buying leflunomide online, stick to licensed pharmacies that require a valid prescription. Look for clear contact information, a physical address, and a pharmacist who can answer questions. Avoid sites that sell the drug without asking for a prescription; they often sell counterfeit or unsafe products.

In summary, leflunomide can be a powerful ally against rheumatoid arthritis when used correctly. Keep up with lab tests, watch for side effects, and stay clear about any other meds or supplements you’re taking. And if you ever need to order it online, choose a reputable pharmacy that follows local regulations. With the right precautions, you’ll get the most benefit and the least risk from this medication.