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Tag: methotrexate NSAID interaction

Methotrexate and NSAIDs: How They Affect Kidney Function and Drug Levels
  • January 24 2026
  • 3 Comments
  • Colin Winthrop

Methotrexate and NSAIDs: How They Affect Kidney Function and Drug Levels

Methotrexate and NSAIDs can dangerously interact, reducing kidney clearance and raising toxic drug levels. Learn who’s at risk, which NSAIDs are safest, and how to prevent life-threatening kidney injury.

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